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Neurotensin increases colonic motility.

K Thor, S Rosell

Gastroenterology

|January 1, 1986

Summary

This summary is machine-generated.

Neurotensin, a peptide, significantly increases colonic motility in the ascending colon and rectosigmoid area. This effect on gut movement was observed in both healthy subjects and patients with gastrointestinal conditions.

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Area of Science:

Gastroenterology
Neuroendocrinology
Physiology

Background:

Neurotensin is a neuropeptide found in the gastrointestinal tract.
Its role in regulating colonic motility is not fully understood.

Purpose of the Study:

To investigate the effects of intravenous neurotensin on colonic motility in healthy volunteers and patients.

Main Methods:

Neurotensin was infused intravenously at 12 pmol/kg/min for 30 minutes.
Colonic motility was measured in the ascending colon, rectosigmoid area, and at the splenic flexure.
Motility index and contraction duration were analyzed.

Main Results:

Neurotensin increased contraction duration in the ascending colon (76%) and rectosigmoid area (46%).

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Motility index significantly rose in the ascending colon and rectosigmoid area.

Increased sensation of intestinal movement and bowel content discharge were reported.

Conclusions:

Neurotensin enhances colonic motility, particularly in the ascending colon of patients and the rectosigmoid area of healthy subjects after a delay.
The peptide plays a role in regulating gastrointestinal transit.