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Two-Dimensional TiS2 Nanosheet- and Conjugated Polymer Nanoparticle-Based Composites for Sensing Applications
D Yeniterzi1,2, S C Cevher3, S Kandur Baglicakoglu4
1Department of Biomedical Engineering, Necmettin Erbakan University, 42090 Konya, Türkiye.
Langmuir : the ACS Journal of Surfaces and Colloids
|October 15, 2024
Summary
This study introduces novel polymer nanoparticles combined with titanium disulfide nanosheets for detecting catechol. This new biosensor offers a sensitive, selective, and cost-effective method for analyzing phenolic compounds in real-world samples.
Area of Science:
- Materials Science
- Nanotechnology
- Electrochemistry
Background:
- Phenolic compounds require accurate assessment in various applications.
- Developing sensitive and selective biosensors is crucial for detecting these compounds.
- Conjugated polymer nanoparticles (P-PimBzBt NPs) and 2D titanium disulfide (TiS2) nanosheets offer potential for advanced biosensing.
Purpose of the Study:
- To develop and characterize novel conjugated polymer nanoparticles (P-PimBzBt NPs) composited with 2D-TiS2 nanosheets for electrochemical tyrosinase (TYR)-based catechol detection.
- To investigate the molecular interactions between P-PimBzBt NPs and TiS2 using computational methods.
- To evaluate the performance, selectivity, and applicability of the fabricated nanobiosensor in real samples.
Main Methods:
- Synthesis and characterization of TiS2@P-PimBzBt NP composites.
- Density Functional Theory (DFT) and molecular dynamics simulations to study interfacial interactions.
- Electrochemical techniques including Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS).
- Surface analysis using Field Emission Scanning Electron Microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDS).
Main Results:
- TiS2 nanosheets enhance interfacial interactions with P-PimBzBt NPs via electrostatic forces.
- The SPE/TiS2@P-PimBzBt NPs/TYR nanobiosensor demonstrated a detection range of 3.0-27.5 μM for catechol.
- Achieved a low Limit of Detection (LOD) of 0.33 μM and high sensitivity of 3.89 μA/μM·cm².
- Exhibited excellent selectivity against common interfering substances and high accuracy in real sample analysis (tap water, black tea).
Conclusions:
- The P-PimBzBt NPs functionalized with 2D-TiS2 are suitable electrode materials for electrochemical biosensing.
- The developed nanobiosensor is inexpensive, fast-responding, and highly selective for catechol detection.
- This platform shows significant potential for practical applications in environmental and food analysis.
