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Area of Science:

  • Psychopharmacology
  • Neuroscience
  • Ethnopharmacology

Background:

  • Increasing interest in psychedelic therapeutics.
  • Limited research on inhaled N,N-Dimethyltryptamine (DMT).
  • Poor understanding of factors influencing inhaled DMT use frequency.

Purpose of the Study:

  • Investigate correlates of inhaled DMT use frequency.
  • Understand user motivations, substance sources, and risk perceptions.
  • Inform harm reduction and educational strategies for inhaled DMT.

Main Methods:

  • Online survey of nearly 400 inhaled DMT users.
  • Collected data on substance use histories, motivations, DMT sources, and risk perceptions.
  • Recruited participants from internet sites focused on DMT.

Main Results:

  • Curiosity, broader psychedelic interest, and spiritual benefits were key motivations for initiation.
  • Prior use of other psychedelics (especially ayahuasca) and self-extraction correlated with higher inhaled DMT frequency.
  • Most users obtained DMT from friends, finding it slightly difficult to procure.
  • Common use settings included private homes, alone or in small groups, often via glass pipe.
  • Positive experiences included psychological cleansing; challenges involved difficult integration and aversive experiences.
  • Participants generally rated inhaled DMT as safe.

Conclusions:

  • Inhaled DMT use is associated with specific motivations and user profiles.
  • Harm reduction and education are needed, given media coverage of potential therapeutic effects.
  • Further research is warranted to understand the correlates and impacts of inhaled DMT use.