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  11. Overlapping Group Between Non-alcoholic Fatty Liver Disease And Metabolic Associated Fatty Liver Disease Better For Liver Research

Overlapping group between non-alcoholic fatty liver disease and metabolic associated fatty liver disease better for liver research

Yu-Ming Cheng1, Tsung-Han Hsieh2, Chia-Chi Wang3

  • 1Department of Gastroenterology and Hepatology Tung's Taichung MetroHarbor Hospital Taichung City Taiwan.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|October 15, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Metabolic associated fatty liver disease (MAFLD) criteria identify a high-risk group within non-alcoholic fatty liver disease (NAFLD) patients. This overlapping fatty liver disease (FLD) group exhibits worse metabolic profiles and advanced liver fibrosis.

Area of Science:

  • Hepatology
  • Metabolic Diseases
  • Cardiovascular Health

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous condition.
  • Metabolic associated fatty liver disease (MAFLD) was proposed to refine NAFLD diagnosis.
  • The clinical characteristics of overlapping FLD remain largely unknown.

Purpose of the Study:

  • To investigate the clinical characteristics of patients with overlapping fatty liver disease (FLD).
  • To compare outcomes between overlapping FLD, NAFLD alone, and MAFLD alone groups.
  • To identify factors associated with advanced liver fibrosis in overlapping FLD patients.

Main Methods:

  • Utilized data from the Taiwan Bio-Bank database.
  • Defined NAFLD by hepatic steatosis on ultrasound, excluding other chronic liver diseases.
Keywords:
metabolic associated fatty liver diseasemetabolic dysfunctionnon‐alcoholic fatty liver diseasenon‐alcoholic fatty liver disease fibrosis score

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  • Defined MAFLD by hepatic steatosis plus metabolic dysfunction (obesity, type 2 diabetes, or metabolic risk abnormalities).
  • Identified three groups: overlapping FLD, NAFLD alone, and MAFLD alone.
  • Defined advanced liver fibrosis as NAFLD fibrosis score (NFS) >0.675.

    • Main Results:

    • Included 8,038 NAFLD participants; 91.8% had overlapping FLD.
    • Overlapping FLD patients were older, more frequently male, and had worse metabolic profiles.
    • Overlapping FLD patients showed higher NFS and increased carotid plaque prevalence compared to NAFLD alone.
    • Age, hypertension, diabetes mellitus, and BMI were associated with advanced liver fibrosis in overlapping FLD.

    Conclusions:

    • Overlapping FLD represents a high-risk population within NAFLD patients, valuable for research.
    • MAFLD criteria address the heterogeneity issue present in the NAFLD definition.
    • Identifying overlapping FLD aids in targeted research and potentially clinical management.
    overlapping fatty liver disease