Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD49d: beyond a prognostic marker in CLL.

Blood·2026
Same author

Pitfalls in Detecting MET Exon 14 Skipping Variants by DNA- and RNA-Based Next-Generation Sequencing Technologies in a Large Real-World Cohort and Results of the First Multinational External Quality Assessment Schemes.

The Journal of molecular diagnostics : JMD·2026
Same author

Chronic Lymphocytic Leukemia Through the Spectrum: Frontline Therapy, Sequencing With Subsequent Therapy, and Treatment of Double-Refractory Patients.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2026
Same author

Distributed Clonal Deletion Prevents Autoimmune Disease Progression.

bioRxiv : the preprint server for biology·2026
Same author

Mannose-Conjugation Resolves the Efficiency-Toxicity Trade-Off in Amine Functionalized Silica Nanocarriers via Tunable pH-Responsive Drug Release.

ACS applied materials & interfaces·2026
Same author

An agentic framework for autonomous scientific discovery in cancer pathology.

Nature medicine·2026

Related Experiment Video

Updated: Jun 10, 2025

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.3K

The immune landscape in brain metastasis.

Luca D Schreurs1,2, Alexander F Vom Stein1,2, Stephanie T Jünger3

  • 1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany.

Neuro-Oncology
|October 15, 2024
PubMed
Summary

New insights into the brain metastatic niche reveal unique immune cell landscapes. Understanding these immune cells and their interactions offers promise for novel brain metastasis therapies.

Keywords:
brain metastasiscombination therapyimmune microenvironmentmetastatic niche

More Related Videos

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

26.5K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

7.2K

Related Experiment Videos

Last Updated: Jun 10, 2025

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.3K
Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

26.5K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

7.2K

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Metastasis

Background:

  • Brain metastasis prognosis is poor despite current treatments.
  • The brain's immune microenvironment in metastasis is poorly understood.
  • Novel therapeutic targets are urgently needed.

Purpose of the Study:

  • To review the immune cell landscape in brain metastasis.
  • To explore immune cell interactions within the metastatic brain niche.
  • To summarize therapeutic strategies targeting the brain immune microenvironment.

Main Methods:

  • Analysis of high-throughput and spatially resolved single-cell data.
  • Review of current literature on brain metastatic immune cells.
  • Examination of preclinical and clinical trial data.

Main Results:

  • Brain metastasis exhibits a unique immune landscape distinct from primary tumors.
  • Tumor-associated macrophages (microglia and monocyte-derived) and T cells are key players.
  • Immune cell phenotypes and interactions are crucial in metastasis pathogenesis.

Conclusions:

  • Targeting the brain's immune microenvironment holds therapeutic potential.
  • Understanding immune cell dynamics is key to developing new treatments.
  • Combination therapies may improve outcomes for brain metastasis patients.