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Assessing the stability of daptomycin in icodextrin-based peritoneal dialysis solution.
Hiroyuki Suzuki1,2, Kasumi Kudo2,3, Takashi Uno2
1Division of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Summary
Daptomycin (DAP) in icodextrin peritoneal dialysis (PD) solution remains stable for 72 hours at room temperature and 12 hours at 37°C, aiding peritonitis treatment. This stability is crucial for effective outpatient management.
Area of Science:
- Pharmacokinetics and Drug Stability
- Peritoneal Dialysis Solutions
- Antimicrobial Therapy
Background:
- Antimicrobial stability in peritoneal dialysis (PD) solutions is vital for successful peritonitis treatment.
- This study assessed daptomycin (DAP) stability in an icodextrin-based PD solution.
Purpose of the Study:
- To evaluate the stability of daptomycin (DAP) in NICOPELIQ® Peritoneal Dialysis Solution.
- To determine DAP concentrations and identify any structural changes over time.
Main Methods:
- Daptomycin (350 mg) was added to NICOPELIQ® PD solution (1,260 mL).
- Samples were collected from 0 to 336 hours.
- DAP concentration was quantified using HPLC; structural analysis of unidentified peaks was performed using LC-MS/MS.
Main Results:
- Daptomycin retained over 90% of its initial concentration for 72 hours at room temperature and 12 hours at 37°C.
- Unidentified peaks were detected and identified as anhydrated daptomycin.
Conclusions:
- Daptomycin exhibits adequate stability in icodextrin-based PD solutions under tested conditions.
- These findings support the use of daptomycin for outpatient management of peritonitis in PD patients.
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