Utility of The Paris System for Reporting Urinary Cytology in patients with HPV-positive urinary tract carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Human papillomavirus (HPV)-positive urinary tract carcinomas (UTCas) can be identified using The Paris System (TPS) criteria, but HPV association may be missed. Basaloid cells or atypical squamous cells (ASCs) may indicate HPV screening needs.
Area Of Science
- Uropathology
- Cytopathology
- Oncology
Background
- Human papillomavirus (HPV)-positive urinary tract carcinomas (UTCas) possess unique characteristics.
- Cytomorphologic analysis of HPV-positive UTCas in urine cytology has not been previously reported.
- This study investigates HPV-positive UTCa using The Paris System for Reporting Urinary Cytology (TPS) criteria.
Purpose Of The Study
- To evaluate the cytomorphologic findings of HPV-positive urinary tract carcinomas (UTCas) in urine cytology specimens.
- To assess the applicability of The Paris System for Reporting Urinary Cytology (TPS) criteria for identifying these tumors.
- To identify potential cytomorphologic indicators for HPV screening in urine specimens.
Main Methods
- Retrospective review of surgical specimens with confirmed HPV-positive UTCa.
- Analysis of concurrent urine cytology specimens using TPS criteria.
- Evaluation of cytomorphologic features including high-grade urothelial carcinoma (HGUC), atypical squamous cells (ASCs), and basaloid features.
Main Results
- Sixteen cytology specimens from eight patients with HPV-positive UTCa were analyzed.
- TPS criteria identified atypical findings in eight cases, including five HGUC, one suspicious for HGUC, and two atypical urothelial cases.
- Common features included basaloid clusters (75%) and ASCs (50%), with urothelial cell hyperchromasia (88%) and hypochromasia (50%) frequently observed.
Conclusions
- The Paris System (TPS) criteria can reliably identify high-grade urothelial carcinoma (HGUC) in HPV-positive urinary tract carcinomas (UTCas).
- HPV-positive UTCas may not be recognized as HPV-associated based solely on initial cytology.
- The presence of basaloid cells or ASCs warrants consideration for HPV screening in urine cytology.
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