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Updated: Jun 10, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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PRMT5: splicing up tolerance

Rathan Kumar1,2, Parvathi Ranganathan1

  • 1Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center and.

The Journal of Clinical Investigation
|October 15, 2024
PubMed

Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance. Using conditional KO mice, the authors showed that thymic deficiency of Prmt5 predisposed mice to developing autoimmune diseases while enhancing antitumor efficacy. These studies provide insight into the role of PRMT5 in shaping the T cell repertoire with implications for the development of therapies.

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