Related Experiment Video
Updated: Jun 10, 2025

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
Published on: November 16, 2012
Surface-engineered bacteria in drug development
Charles Dahlsson Leitao1, Stefan Ståhl1, John Löfblom1
1Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Abstract:
Bacterial surface display in combination with fluorescence-activated cell sorting is a versatile and robust system and an interesting alternative approach to phage display for the generation of therapeutic affinity proteins. The system enables real-time monitoring and sorting of cell populations, which presents unique possibilities for drug development. It has been used to develop several affibody molecules currently being evaluated preclinically for the treatment and diagnosis of, for example, cancer and neurodegenerative diseases. Additionally, it can be implemented in other areas of drug design, such as for mapping epitopes and evolving enzyme specificities.
Related Concept Videos
Antibiotic Selection
Bacterial Signaling
Microorganisms in Medicine and Therapeutics
Development of Antibiotic Resistance
Biological Methods for Microbial Control
Biosynthesis in Bacteria

