Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

4.9K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
4.9K
Structure and Function of Platelets01:18

Structure and Function of Platelets

1.0K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.0K
Introduction to Hemostasis01:05

Introduction to Hemostasis

6.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective factors and critical mucosal thickness for the stability of the peri-implant soft tissue margin over 5 years: A longitudinal cohort study.

Journal of periodontology·2026
Same author

Accuracy of scannable anatomic healing abutments for implant-supported crown and fixed partial prostheses: An in vitro comparison with conventional scan bodies.

The Journal of prosthetic dentistry·2026
Same author

Horizontal Ridge Augmentation Using an rhBMP-2 Loaded Volume-Stable Collagen Matrix Compared to Guided Bone Regeneration: A Preclinical In Vivo Study.

Journal of clinical periodontology·2026
Same author

Prevalence of Periodontitis in Africa: A Systematic Review and Meta-Analysis of Epidemiological Studies Up to 2025.

Journal of clinical periodontology·2026
Same author

The Tunneled Coronally Advanced Flap (TCAF) for Root Coverage Procedures: Rationale, Indications, and a Novel Papilla-Based Decision Tree.

Journal of periodontal research·2026
Same author

Papilla-Preserving Gingival Fiber Retention Osseous Surgery in the Anterior Maxilla: A Novel Clinical Technique.

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]·2026

Related Experiment Video

Updated: Jun 10, 2025

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
08:14

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

12.9K

Autologous platelet concentrates in root coverage procedures.

Shayan Barootchi1,2,3, Lorenzo Tavelli2,3, Maria Elisa Galarraga Vinueza4,5

  • 1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Periodontology 2000
|October 15, 2024
PubMed
Summary

Platelet-rich fibrin (PRF) significantly improves root coverage for gingival recessions when used with advanced flaps. Optimal results are seen with adequate baseline keratinized tissue width.

Keywords:
evidenced‐based dentistrygingival recessiongrowth factorsperiodontal regenerationtissue engineering

More Related Videos

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.4K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

11.6K

Related Experiment Videos

Last Updated: Jun 10, 2025

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
08:14

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

12.9K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.4K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

11.6K

Area of Science:

  • Periodontology
  • Regenerative Medicine

Background:

  • Gingival recessions are common, prompting research into minimally invasive treatments.
  • Autologous platelet concentrates (APCs) are increasingly used biologics in periodontal therapy.
  • Various preparation methods exist for APCs like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF).

Purpose of the Study:

  • To systematically review the efficacy of different APC preparation methods for treating Type 1 gingival recessions.
  • To compare APC effectiveness against flap advancement alone.
  • To assess factors influencing treatment outcomes with APCs.

Main Methods:

  • Systematic literature search of randomized clinical trials.
  • Focus on APCs (PRP, PRF, etc.) for Type 1 gingival recession treatment.
  • Comparison with coronally advanced flap alone as control.

Main Results:

  • Platelet-rich fibrin (PRF) significantly enhances root coverage outcomes compared to flap advancement alone.
  • Baseline keratinized tissue width positively correlates with PRF efficacy.
  • Greater baseline keratinized tissue width leads to better root coverage with PRF.

Conclusions:

  • PRF is an effective biologic adjunct for treating Type 1 gingival recessions.
  • Keratinized tissue width is a key factor for successful PRF treatment.
  • Further research is needed on PRF with different materials and against other biologics.