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Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients

Sean McCallion1, Thomas McLarnon1, Eamonn Cooper1

  • 1Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UK.

Cells
|October 15, 2024
PubMed
Abstract

Insights

Cellular senescence proteins CKAP4 and PTX3 are elevated in acute kidney injury (AKI) and chronic kidney disease (CKD) patients. These findings suggest CKAP4 may serve as a prognostic biomarker for kidney disease progression.

Area of Science:

  • Gerontology
  • Nephrology
  • Molecular Biology

Background:

  • Cellular senescence, an irreversible growth arrest, is linked to aging and chronic diseases.
  • Its role in acute kidney injury (AKI) and chronic kidney disease (CKD) remains unclear, though elevated senescence is suspected.
  • AKI and CKD patients exhibit signs of accelerated aging.

Purpose of the Study:

  • To identify key senescence biomarkers in AKI and CKD patients.
  • To compare senescence markers in kidney disease patients against controls with other chronic aging diseases.
  • To utilize OLINK proteomics for biomarker discovery.

Main Methods:

  • Employed OLINK proteomics technology.
  • Analyzed protein expression in AKI and CKD patients.
  • Compared findings against a control group with chronic aging diseases.

Main Results:

  • CKAP4 and PTX3 proteins were significantly upregulated in AKI and CKD patients (p < 0.0001).
  • These upregulated proteins suggest a role in the pathogenesis of kidney diseases.
  • CKAP4 showed differential expression in both AKI and CKD compared to controls.

Conclusions:

  • CKAP4 and PTX3 are key senescence biomarkers in kidney disease.
  • CKAP4 may serve as a prognostic biomarker for both AKI and CKD.
  • Further research is warranted to elucidate the role of these proteins in kidney disease development.
Keywords:
acute kidney injurybiomarkerchronic kidney diseasemachine learningsenescence

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