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PP2A negatively regulates NK cell T-bet expression and anti-tumor effector function

Yui Shinzawa1, Daisuke Hara1, Yuki Shinguryo1

  • 1Section of Host Defences, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

International Immunology
|October 15, 2024
PubMed
Summary

Protein phosphatase 2A (PP2A) negatively regulates T-bet expression in natural killer (NK) cells. Inhibiting PP2A enhances NK cell anti-tumor immunity via mTOR signaling, improving cancer treatment outcomes.

Keywords:
effector functionmTOR

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