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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
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Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Alessia d'Aiello1, Simone Filomia2, Mattia Brecciaroli2
1Department of Cardiovascular Sciences- CUORE, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy.
Current Atherosclerosis Reports
|October 15, 2024
Summary
Atherosclerotic cardiovascular disease (ACVD) involves immune mechanisms. Anti-inflammatory therapies, like CANTOS, reduce cardiovascular risk, highlighting new targets for residual risk reduction.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Pharmacology
Background:
- Atherosclerotic cardiovascular disease (ACVD) is a leading global cause of death.
- Standard risk factor management leaves residual cardiovascular risk.
- Immunological pathways in atherosclerosis offer potential therapeutic targets.
Purpose of the Study:
- To review molecular mechanisms of ACVD immuno-pathogenesis.
- To discuss anti-inflammatory effects of approved cardiovascular therapies.
- To examine immunomodulatory therapies for ACVD and identify new targets.
Main Methods:
- Review of molecular mechanisms in ACVD immuno-pathogenesis.
- Analysis of pleiotropic anti-inflammatory effects of cardiovascular drugs.
- Evaluation of evidence for immunomodulatory therapies in ACVD.
Main Results:
- The CANTOS trial demonstrated cardiovascular risk reduction with anti-inflammatory therapy.
- Common drugs (SGLT2i, PCSK9i) show pleiotropic anti-inflammatory effects.
- Emerging therapies target inflammatory compounds (IL-2, PTPN22, CD31) to reduce residual risk.
Conclusions:
- Targeting immunological mechanisms is crucial for addressing residual ACVD risk.
- Precision medicine approaches can identify novel therapeutic targets and biomarkers.
- Further clinical and translational research is essential for advancing ACVD treatment.
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