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Related Experiment Video

Updated: May 13, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

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Hypophysitis in COVID-19: a systematic review.

Sara Menotti1, Luigi di Filippo2, Umberto Terenzi2

  • 1Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Via Olgettina 60, 20132, Milan, Italy. menotti.sara@hsr.it.

Pituitary
|October 15, 2024
PubMed
Summary
This summary is machine-generated.

Hypophysitis following COVID-19 is rare but presents with distinct symptoms like headache and polyuria. Further research is needed to understand long-term pituitary function and underlying mechanisms.

Keywords:
Angiotensin-vasopressin deficiencyAutoimmuneCOVID-19HypophysitisHypothalamusPituitarySARS-CoV-2

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Neurology

Background:

  • COVID-19 has been associated with various neurological complications, including rare cases of hypophysitis.
  • Understanding hypophysitis in COVID-19 patients is crucial for diagnosis and management.

Approach:

  • A systematic literature review was conducted using MEDLINE (PubMed) in July 2024.
  • Seven cases of post-COVID-19 hypophysitis were analyzed for demographics, symptoms, imaging, diagnosis, management, and outcomes.

Key Points:

  • Seven cases identified (4 female, 3 male; median age 37).
  • Symptoms included headache, polyuria, polydipsia, and hypopituitarism (85%).
  • MRI findings varied; no biopsies performed. Glucocorticoid treatment used in 57%.

Conclusions:

  • Post-COVID-19 hypophysitis has distinct features compared to autoimmune hypophysitis.
  • Longer follow-up is necessary to assess lasting pituitary function and radiological changes.
  • Future research should investigate anti-pituitary antibodies and pathophysiological mechanisms.