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Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β

Mitsuhiro Sekiguchi1, Mafumi Horiuchi2, Yuta Tozawa3

  • 1Graduate School of Bioresources and Environmental Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa, 921-8836, Japan. m-seki@ishikawa-pu.ac.jp.

Journal of Natural Medicines
|October 15, 2024
PubMed

Keywords:
Sargassum siliquastrumAlzheimer’s diseaseAmyloid βBrown algaMeroterpenoid

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
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