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Treatment for resectable esophageal and lung cancers is evolving. Neoadjuvant therapies and immunotherapy are increasingly used to improve outcomes before surgery.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Thoracic Surgery

Background:

  • Review of recent prospective surgical studies on resectable esophageal and lung cancer.
  • Focus on advancements in treatment modalities for these cancers.

Purpose of the Study:

  • To analyze current prospective surgical trials for resectable esophageal and lung cancer.
  • To understand the evolving landscape of multimodal therapy and immunotherapy.

Main Methods:

  • Narrative literature review of studies from 2010-2023.
  • Keywords: 'resectable esophageal cancer', 'multimodal therapy', 'resectable non-small cell lung cancer'.

Main Results:

  • Esophageal cancer: Neoadjuvant chemoradiation improves outcomes; immunotherapy shows promise in induction/adjuvant settings.
  • Lung cancer: Sublobar resection for specific early-stage disease; neoadjuvant/adjuvant immunotherapy for stages II-IIIA.

Conclusions:

  • Treatment for resectable esophageal and lung cancers is rapidly changing.
  • Preoperative optimization and minimizing morbidity are key focuses.
  • Personalized medicine approaches are on the horizon.