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Related Concept Videos

Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

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Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
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Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

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Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either...
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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
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Diffusion Models for Imperceptible and Transferable Adversarial Attack.

Jianqi Chen, Hao Chen, Keyan Chen

    IEEE Transactions on Pattern Analysis and Machine Intelligence
    |October 15, 2024
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces DiffAttack, a new method for creating visually imperceptible adversarial attacks using diffusion models. DiffAttack enhances transferability to black-box models, outperforming existing techniques.

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    Area of Science:

    • Computer Vision
    • Artificial Intelligence
    • Machine Learning

    Background:

    • Existing adversarial attacks often create perceptible perturbations in image RGB space.
    • Unrestricted attacks lack transferability to black-box models.
    • Visual imperceptibility and transferability are key challenges in adversarial attacks.

    Purpose of the Study:

    • To propose a novel adversarial attack method, DiffAttack, that achieves both visual imperceptibility and transferability.
    • To leverage the generative and discriminative capabilities of diffusion models for crafting adversarial examples.
    • To address the limitations of existing adversarial attack strategies.

    Main Methods:

    • Crafting perturbations in the latent space of diffusion models instead of pixel space.
    • Utilizing content-preserving structures to generate human-insensitive perturbations with semantic clues.
    • Deceiving diffusion models by distracting their attention to improve transferability.

    Main Results:

    • DiffAttack generates imperceptible adversarial examples that are transferable across diverse model architectures (CNNs, Transformers, MLPs).
    • The proposed method demonstrates superiority over iterative, GAN-based, and ensemble attacks.
    • Experiments were conducted on ImageNet, CUB-200, and Standford Cars datasets, validating effectiveness against various defenses.

    Conclusions:

    • DiffAttack is the first method to integrate diffusion models into adversarial attacks, offering a new direction.
    • The approach successfully balances imperceptibility and transferability, outperforming prior methods.
    • Future research can explore further advancements in diffusion-based adversarial attacks.