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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
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Current and Emerging Radiotracers in Molecular Cardiovascular Imaging
Shruti S Joshi1, Jolien Geers1,2, Alessia Gimelli3
1BHF Centre for Cardiovascular Science, The University of Edinburgh, United Kingdom (S.S.J., J.G., D.E.N., M.R.D.).
Circulation. Cardiovascular Imaging
|October 15, 2024
Summary
Molecular nuclear imaging, including positron emission tomography and single-photon emission computed tomography, offers molecular insights into cardiovascular disease activity. These advanced techniques enhance diagnosis, therapy development, and personalized patient care in cardiovascular medicine.
Area of Science:
- Cardiovascular medicine
- Medical imaging
- Nuclear medicine
Background:
- Traditional cardiovascular imaging (echocardiography, CT, CMR) assesses structure and function.
- These methods often lack direct insight into cardiovascular disease activity.
- Molecular nuclear imaging bridges this gap by visualizing disease at molecular/cellular levels.
Purpose of the Study:
- To review the role of cardiovascular molecular imaging.
- To highlight current and potential applications in diagnosing and managing cardiovascular disease.
- To discuss the impact of advancements on precision medicine.
Main Methods:
- Review of molecular nuclear imaging techniques (PET, SPECT).
- Emphasis on applications in cardiovascular disease.
- Discussion of technological advancements (scanners, radiotracers, software).
Main Results:
- Molecular imaging provides direct insights into disease activity.
- PET and SPECT visualize disease processes at molecular and cellular levels.
- Advancements are enhancing diagnostic and therapeutic capabilities.
Conclusions:
- Cardiovascular molecular imaging is crucial for understanding disease mechanisms.
- It accelerates targeted therapy development and personalized patient care.
- Molecular imaging is integral to the future of precision cardiovascular medicine.
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