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Cerebral Venous Sinus Thrombosis: Current Updates in the Asian Context
Angel Miraclin T1, Deepti Bal1, Ivy Sebastian2
1Department of Neurological Sciences, Christian Medical College, Vellore, India.
Cerebral venous sinus thrombosis (CVT) is more common in Asia, particularly affecting young women. Key risk factors include dehydration and tropical infections, with anticoagulation offering good outcomes.
Area of Science:
- Neurology
- Vascular Medicine
- Public Health
Background:
- Cerebral venous sinus thrombosis (CVT) is a significant cause of stroke in Asian nations, with distinct epidemiological patterns compared to Western countries.
- South Asia accounts for a substantial portion of stroke cases in women, highlighting gender-specific vulnerabilities.
- Existing CVT research predominantly originates from Western populations, necessitating a focus on the Asian context for relevant insights.
Purpose of the Study:
- To review the evaluation and management strategies for Cerebral Venous Sinus Thrombosis (CVT) specifically within the Asian demographic.
- To highlight the unique epidemiological features, gender predispositions, and risk factors pertinent to CVT in Asia.
- To provide a comprehensive overview relevant to clinicians managing CVT patients in Asian healthcare settings.
Main Methods:
- Systematic review of existing literature on Cerebral Venous Sinus Thrombosis (CVT) in Asian populations.
- Analysis of epidemiological data, risk factors, and clinical presentations specific to South Asia.
- Evaluation of current management guidelines and treatment outcomes for CVT in the Asian context.
Main Results:
- CVT incidence is higher in Asia than in Western regions, with young age and female gender (especially during pregnancy/puerperium) being critical risk factors.
- Tropical infections (malaria, scrub typhus) and inherited thrombophilia are prevalent predisposing factors for CVT in Asian cohorts.
- Anticoagulation and supportive care yield excellent outcomes; newer anticoagulants are safe and effective, while endovascular treatments and decompressive hemicraniectomy offer benefits in specific refractory cases.
Conclusions:
- Cerebral Venous Sinus Thrombosis (CVT) represents a substantial stroke burden in South Asia, with unique risk factors.
- Establishing robust registries is crucial for understanding CVT's natural history and developing resource-tailored management strategies in Asia.
- Early intervention with anticoagulation and appropriate supportive/surgical measures improves outcomes for CVT patients in the Asian context.
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