Chitosan-based electrospun fibers for bone-tissue engineering: Recent research advancements

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Polymer Chemistry

Background:

• Chitosan is a sustainable biopolymer with versatile properties beneficial for biomedical applications.
• Its charged nature makes it ideal for scaffold fabrication in bone tissue engineering.
• Electrospinning is a scalable method for creating porous nanocomposite structures from chitosan.

Purpose of the Study:

• To provide a comprehensive review of chitosan-based electrospun materials for bone tissue engineering.
• To address the existing knowledge gap in the thorough review of this research area.
• To discuss the properties of chitosan, electrospinning factors, material types, and recent advancements.

Main Methods:

• Literature review of research on chitosan-based electrospun materials for bone tissue engineering.
• Discussion of chitosan properties relevant to bone tissue engineering.
• Analysis of electrospinning parameters and chitosan-based material types.

Main Results:

• Chitosan possesses properties suitable for bone tissue engineering scaffolds.
• Electrospinning is an effective method for fabricating chitosan-based nanocomposite structures.
• Recent advancements and various types of chitosan-based electrospun materials have been identified.

Conclusions:

• Chitosan-based electrospun materials show significant promise for bone tissue engineering.
• Further research and a clear perspective on future technology are needed.
• This review consolidates current knowledge and identifies future directions.