EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!
Ryan Alexander1,2, Blake Kassmeyer3, Ryan Lennon3
1Department of Internal Medicine, Mayo Clinic Rochester, Rochester, USA. alexander.ryan2@mayo.edu.
Background And Aims:
Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.
Methods:
Retrospective review of 101 patients with histologic PPI-responsive EoE.
Results:
52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.
Conclusions:
Patients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.
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