Curcumin-Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole...

Area of Science:

• Electrochemistry
• Materials Science
• Analytical Chemistry

Background:

• Dipyridamole (DIP) is a medication with critical therapeutic applications.
• Accurate and sensitive detection methods for DIP are essential for quality control and environmental monitoring.
• Existing methods may lack the sensitivity, speed, or cost-effectiveness required for routine analysis.

Purpose of the Study:

• To develop a novel, rapid, and cost-effective disposable electrochemical sensor for dipyridamole (DIP) determination.
• To utilize molecularly imprinted polymer (MIP) technology combined with curcumin (CUR) as a functional monomer for enhanced sensor performance.
• To validate the sensor's efficacy in quantifying DIP in real-world samples like pharmaceutical preparations and tap water.

Main Methods:

• Fabrication of a molecularly imprinted polymer (MIP) on a pencil graphite electrode (PGE) via potentiodynamic electrochemical polymerization using curcumin (CUR) as a functional monomer and DIP as a template.
• Optimization of polymerization conditions including pH, monomer-template ratio, scan rate, and cyclic voltammetric cycles.
• Investigation of DIP voltammetric behavior at the MIP-modified electrode (MIP_PGE).
• Quantification of DIP using differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV).

Main Results:

• The MIP-based sensor demonstrated efficient and selective recognition of dipyridamole.
• Optimized conditions yielded sensitive detection with linear ranges of 5.00 × 10^-8-1.00 × 10^-5 mol/L (DPV) and 5.00 × 10^-9-1.00 × 10^-7 mol/L (AdSDPV).
• Achieved low limits of detection: 1.47 × 10^-8 mol/L (DPV) and 3.96 × 10^-9 mol/L (AdSDPV).
• The sensor successfully quantified DIP in pharmaceutical and tap water samples.

Conclusions:

• The developed MIP-based electrochemical sensor offers a promising tool for sensitive and selective dipyridamole determination.
• The use of curcumin as a functional monomer and potentiodynamic polymerization provides a rapid and effective sensor fabrication method.
• The sensor's applicability in real samples highlights its potential for practical analytical applications in quality control and environmental monitoring.