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Pleural Disorders: Types and Brief Description

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...

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Pleural Effusion Overview
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Clinical Manifestations:

Pleural Effusion I: Introduction

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Related Experiment Video

Updated: Jun 10, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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Published on: December 21, 2019

Malignant Pleural Mesothelioma: A Comprehensive Review.

Molly Jain¹, Morgan Kay Crites¹, Patricia Rich¹

¹Parkview Health, Fort Wayne, IN 46845, USA.

Journal of Clinical Medicine

|October 16, 2024

Summary

Malignant pleural mesothelioma (MPM) is a serious asbestos-linked cancer. This review covers recent research on its diagnosis, biomarkers, and treatment options for better patient outcomes.

Keywords:

asbestos biomarkers chemotherapy malignant pleural mesothelioma mesothelioma radiotherapy surgery

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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

Oncology
Pathology
Environmental Health

Background:

Mesotheliomas are tumors of serosal membranes, often linked to asbestos exposure.
Malignant pleural mesothelioma (MPM) predominantly affects males, with a poor prognosis and rapid progression.
Asbestos exposure causes inflammation, cell division disruption, and genetic mutations (e.g., BAP1, CDKN2A, NF) leading to MPM.

Purpose of the Study:

To provide a comprehensive analysis of current research on malignant pleural mesothelioma.
To review the latest biomarkers, diagnostic methods, and management strategies for MPM.
To consolidate information on evaluation and treatment options for MPM.

Main Methods:

Systematic review of recent scientific literature.
Analysis of diagnostic imaging techniques (CT, MRI, PET).
Evaluation of current therapeutic modalities including surgery, chemotherapy, immunotherapy, and radiation therapy.

Main Results:

MPM is strongly associated with long-term asbestos exposure.
Key genetic mutations (BAP1, CDKN2A, NF) are frequently observed in pleural mesothelioma.
Advanced imaging and a combination of treatment strategies are crucial for MPM management.

Conclusions:

Accurate diagnosis of MPM relies on advanced imaging techniques.
Multimodal treatment approaches offer the best management strategy for MPM.
Continued research into biomarkers and novel therapies is essential for improving MPM prognosis.