Arterial Hypertension: Novel Pharmacological Targets and Future Perspectives

Area of Science:

• Cardiology and Hypertension Research
• Pharmacology and Therapeutics
• Public Health and Epidemiology

Background:

• Arterial hypertension (HTN) is a leading global cause of cardiovascular disease and mortality, often complicated by comorbidities like diabetes and obesity.
• Despite available treatments, achieving adequate blood pressure (BP) control remains a significant challenge, impacting vital organs.
• Current healthcare focuses on both pharmacological and non-pharmacological HTN management strategies.

Purpose of the Study:

• To review novel pharmacological targets for arterial hypertension treatment.
• To discuss emerging interventional techniques for resistant hypertension.
• To explore future perspectives in HTN management strategies.

Main Methods:

• Literature review of current and emerging antihypertensive therapies.
• Analysis of novel pharmacological targets addressing HTN pathophysiology and comorbidities.
• Evaluation of interventional procedures for refractory hypertension cases.

Main Results:

• Significant research is directed towards new drug development targeting distinct physiopathological mechanisms.
• Interventional techniques offer alternatives for patients with uncontrolled BP or medication intolerance.
• Poor drug adherence highlights the need for alternative treatment approaches beyond traditional medications.

Conclusions:

• Novel pharmacological targets and interventional methods are crucial for improving hypertension control.
• Future HTN treatment strategies must address medication adherence and explore diverse therapeutic avenues.
• Continued research is essential to overcome the limitations of current antihypertensive treatments.