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  11. The Effect Of Retinoids In Vascular Smooth Muscle Cells: From Phenotyping Switching To Proliferation And Migration

The Effect of Retinoids in Vascular Smooth Muscle Cells: From Phenotyping Switching to Proliferation and Migration

Ioanna Samara1, Amalia I Moula2, Anargyros N Moulas3

  • 1Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

International Journal of Molecular Sciences
|October 16, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Retinoic acid (RA) inhibits vascular smooth muscle cell proliferation and migration, key factors in atherosclerosis development. This review explores RA's potential to reduce atherosclerotic lesions, highlighting its therapeutic promise.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Pharmacology

Background:

  • Atherosclerosis involves vascular smooth muscle cell (VSMC) proliferation, migration, and phenotypic switching.
  • Atherosclerotic cardiovascular disease (ASCVD) arises from plaque buildup in arteries.

Purpose of the Study:

  • To review the effects of retinoic acid (RA) on atherosclerosis pathogenesis.
  • To focus on RA's regulatory role in VSMC phenotype switching, proliferation, and migration.

Main Methods:

  • Literature review of studies on RA and VSMCs in atherosclerosis.
  • Analysis of RA's impact on VSMC behavior and atherosclerotic lesion formation.

Main Results:

  • RA demonstrates significant inhibitory effects on VSMC proliferation, migration, and dedifferentiation.
Keywords:
atherosclerosisretinoic acidvascular smooth muscle cells

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  • RA has been shown to reduce the development of atherosclerotic lesions.

    • Conclusions:

    • Retinoic acid shows promise in mitigating atherosclerosis by targeting VSMC dysfunction.
    • Further clinical studies are needed to confirm RA's safety and efficacy for treating atherosclerosis.