Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study
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View abstract on PubMed
Summary
This summary is machine-generated.Tumor necrosis factor-alpha (TNF-α) genetic variations, specifically the rs1800629 polymorphism, are linked to neuroblastoma (NB) susceptibility and prognosis in Mexican patients. The AA genotype of TNF-α SNP rs1800629 is associated with increased NB risk and poorer outcomes.
Area Of Science
- Oncology
- Genetics
- Immunology
Background
- Tumor necrosis factor-alpha (TNF-α) exhibits pro-tumor effects and is linked to poor prognosis in various cancers.
- Understanding the role of TNF-α genetic polymorphisms and serum levels in neuroblastoma (NB) susceptibility and prognosis is crucial.
Purpose Of The Study
- To investigate the association between TNF-α genetic polymorphisms (rs1800629 and rs361525) and serum levels with susceptibility and prognosis in Mexican NB patients.
Main Methods
- Genotyping of TNF-α SNPs (-308 G>A and -238 G>A) using PCR-RFLP.
- Quantification of serum TNF-α levels via ELISA.
- Statistical analysis of genotype distributions, serum levels, and their correlation with NB risk, histology, and survival.
Main Results
- Significant differences in TNF-α genotype distributions were observed between NB patients and controls.
- The rs1800629 GG/GA genotypes were associated with decreased NB risk, while the AA genotype correlated with increased susceptibility (OR=2.89, p=0.003).
- The rs1800629 AA genotype was linked to unfavorable histology, high-risk NB, and lower event-free survival (p=0.026).
- Circulating TNF-α levels differed significantly between patients and controls, but no correlation with SNP genotypes was found.
- The rs361525 GG genotype was associated with a lower risk of NB (OR=0.2, p=0.006).
Conclusions
- The TNF-α SNP rs1800629, particularly the AA genotype, may be a significant factor in NB susceptibility and prognosis in Mexican patients.
- This polymorphism is potentially involved in NB development, progression, and poorer outcomes, including reduced event-free survival.
- Larger, inter-institutional studies are recommended to further elucidate the contribution of TNF-α genetic polymorphisms to NB risk and prognosis.
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