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Multi-Channel Signals in Dynamic Force-Clamp Mode of Microcantilever Sensors for Detecting Cellular Peripheral Brush.
Qiang Lyu1,2, Fan Pei2, Ying-Long Zhao2
1Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China.
Sensors (Basel, Switzerland)
|October 16, 2024
Summary
Detecting cellular peripheral brush defects is crucial for disease diagnosis. This study models cell mechanics to reveal how the peripheral brush impacts disease detection, potentially identifying cancerous cells using microcantilever signals.
Area of Science:
- Biophysics
- Cell Biology
- Biomaterials
Background:
- Pathological changes in the cellular peripheral brush are linked to diseases like cancer and viral infections.
- Early detection of cellular peripheral brush lesions requires novel diagnostic methods.
Purpose of the Study:
- To develop a new method for detecting cellular peripheral brush lesions.
- To establish a constitutive model for cell mechanics incorporating the peripheral brush and intracellular structure.
Main Methods:
- A piecewise linear viscoelastic constitutive model for cells was developed.
- Laplace transformation and differential quadrature methods were used to solve signal interpretation models.
- Quasi-static and dynamic microcantilever signals were analyzed.
Main Results:
- The peripheral brush significantly influences cell viscoelastic properties and microcantilever signals.
- Multi-channel microcantilever signals, including quasi-static and dynamic data, were analyzed.
- The study clarified the influence mechanisms of the peripheral brush on cell mechanics.
Conclusions:
- The peripheral brush plays a critical role in cell viscoelasticity and microcantilever signal responses.
- A novel mapping method using multi-channel signals shows potential for identifying cancerous cells.
- This approach offers a new avenue for disease detection based on cellular structural analysis.
