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Updated: Jun 10, 2025
08:02
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
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Altered Gut Microbiome Composition in Dogs with Hyperadrenocorticism: Key Bacterial Genera Analysis
Hee-Jun Kang1, Sang-Won Kim1, Seon-Myung Kim2
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Animals : an Open Access Journal From MDPI
|October 16, 2024
Summary
Hyperadrenocorticism in dogs disrupts the gut microbiome, reducing diversity. This dysbiosis persists even after trilostane treatment, impacting metabolic health and suggesting new therapeutic avenues.
Area of Science:
- Veterinary Medicine
- Microbiology
- Endocrinology
Background:
- Hyperadrenocorticism (HAC) is a common endocrine disorder in dogs.
- HAC is linked to various metabolic abnormalities.
- Elevated cortisol levels may impact the gut microbiome (GM).
Purpose of the Study:
- To investigate the gut microbiome composition in dogs with HAC.
- To determine if gut dysbiosis persists after trilostane treatment for HAC.
- To identify specific bacterial changes associated with HAC.
Main Methods:
- Compared GM composition in 15 dogs with HAC and 9 healthy controls.
- Analyzed GM in 5 HAC dogs post-trilostane treatment.
- Utilized Shannon index for diversity and beta diversity analysis for clustering.
Main Results:
- Dogs with HAC exhibited reduced microbiome diversity (Shannon index, p = 0.0148).
- Distinct GM clustering separated HAC dogs from controls (beta diversity, p < 0.003).
- HAC dogs showed increased Proteobacteria, Actinobacteria, Bacteroides, Enterococcus, Corynebacterium, Escherichia, Proteus, and decreased Firmicutes.
Conclusions:
- Gut dysbiosis is present in dogs with HAC.
- Dysbiosis persists post-trilostane treatment, potentially contributing to ongoing metabolic issues.
- Targeting GM dysbiosis may offer novel therapeutic strategies for HAC management.
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