Revisiting HER2 in Prostate Cancer from an Inclusive Perspective: From Biomarkers to Omics.

Area of Science:

• Oncology and Molecular Biology
• Cancer Research
• Health Disparities

Background:

• Human epidermal growth factor receptor 2 (HER2) is implicated in cancer progression and treatment resistance.
• Prostate cancer disproportionately affects Black men, who have higher rates of aggressive disease.
• Current research often lacks racial diversity, hindering understanding of variable outcomes.

Purpose of the Study:

• To review the role of HER2 in prostate cancer, considering race and genetic ancestry.
• To highlight the need for diverse study designs in cancer research.
• To address the underrepresentation of Black men in clinical trials.

Main Methods:

• Literature review of existing studies on HER2 and prostate cancer.
• Analysis of the impact of race and genetic ancestry on HER2 expression and prostate cancer outcomes.
• Examination of the implications of homogeneous study designs.

Main Results:

• HER2 is a significant factor in prostate cancer progression and survival.
• Lack of racial diversity in studies limits comprehensive understanding.
• Emerging data suggests higher HER2 prevalence in Black men, potentially worsening prognosis.

Conclusions:

• Incorporating diverse biospecimens and patient populations, particularly Black men, is crucial for prostate cancer research.
• Understanding the influence of race and ancestry on HER2 is necessary for equitable cancer care.
• Future research must prioritize inclusive methodologies to address health disparities.