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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: Jun 16, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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HPV and Lung Cancer: A Systematic Review.

Telma Sequeira1,2, Rui Pinto3, Carlos Cardoso3

  • 1Serviço de Pneumologia, Instituto Português de Oncologia (IPO), Rua Lima Basto, 1099-023 Lisboa, Portugal.

Cancers
|October 16, 2024
PubMed
Summary

Human Papillomavirus (HPV) infection shows varied rates in lung cancer globally. While its role in lung carcinogenesis is inconclusive, intriguing associations with lung adenocarcinoma and squamous cell carcinoma warrant further investigation.

Keywords:
HPVadenocarcinomalung cancersquamous cell carcinoma

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Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Human Papillomavirus (HPV) is a known carcinogen, but its role in lung cancer is not well-established.
  • Existing research presents conflicting findings regarding HPV prevalence and its etiological contribution to lung cancer.
  • Understanding HPV's impact is crucial for diagnosis, prevention, and treatment strategies in lung cancer.

Purpose of the Study:

  • To systematically review the diagnostic criteria, epidemiology, etiology, and prognosis of HPV infection in lung cancer.
  • To synthesize current evidence on the association between HPV and different types of lung cancer.
  • To identify research gaps and methodological limitations in existing studies.

Main Methods:

  • A PRISMA-guided systematic review of PubMed and Embase databases.
  • Search terms included "lung cancer AND HPV", with a focus on human subject papers.
  • Analysis of 97 studies involving 9098 patients worldwide.

Main Results:

  • Reported HPV infection rates in lung cancer varied significantly (0%–69%) across studies and geographic regions.
  • HPV16/18 were predominant in some areas, but overall association with lung cancer remained inconclusive.
  • Lower HPV prevalence was observed in Asian populations compared to Western cohorts; potential roles in lung adenocarcinoma and squamous cell carcinoma were noted, especially in non-smokers.

Conclusions:

  • The role of HPV in lung carcinogenesis is currently inconclusive, with significant discrepancies in detection methods and sample sources.
  • Further research employing standardized methodologies and larger patient cohorts is essential to clarify HPV's involvement in lung cancer.
  • Intriguing associations suggest HPV may play a role in specific lung cancer subtypes, necessitating continued investigation into its clinical implications.