The Tumor Microenvironment as a Therapeutic Target in Cutaneous T Cell Lymphoma

Louis Boafo Kwantwi1,2,3, Steven T Rosen2,4, Christiane Querfeld1,2,4,5

  • 1Department of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA.

Cancers
|October 16, 2024
PubMed

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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