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Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells

Aun Ali Bangash1,2, Sahir Sultan Alvi1,2, Muhammad Ali Bangash1,2

  • 1South Texas Center of Excellence for Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.

Cancers
|October 16, 2024
PubMed

Insights

Honey shows potential as a natural remedy against pancreatic cancer (PanCa). It inhibits PanCa cell growth and metastasis by targeting ribosome biogenesis and inducing apoptosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Natural Products Research

Background:

  • Pancreatic cancer (PanCa) is a highly lethal malignancy with limited treatment options.
  • Dysregulation of ribosome biogenesis is implicated in PanCa development, progression, and metastasis.
  • Targeting ribosome biogenesis presents a novel therapeutic strategy for PanCa.

Purpose of the Study:

  • To investigate the anti-cancer effects of honey on pancreatic cancer cells.
  • To explore honey's impact on ribosome biogenesis pathways in PanCa.
  • To determine if honey can induce apoptosis and inhibit PanCa cell growth and invasion.

Main Methods:

  • Investigated honey's effect on PanCa cell growth and invasion.
  • Assessed mRNA and protein levels of ribosome biogenesis components (RNA Pol-I subunits, UBTF, c-Myc).
  • Evaluated honey's impact on nucleolar proteins (NCL, FBL, NPM), cell cycle, and apoptosis.

Main Results:

  • Honey significantly inhibited PanCa cell growth and invasion.
  • Honey suppressed key ribosome biogenesis factors (RPA194, RPA135, UBTF, c-Myc) and nucleolar proteins.
  • Honey induced nucleolar stress, G2M cell cycle arrest, and apoptosis in PanCa cells.

Conclusions:

  • Honey demonstrates significant anti-cancer properties against pancreatic cancer.
  • Honey effectively targets ribosome biogenesis and induces apoptosis in PanCa cells.
  • Honey represents a promising natural therapeutic agent for PanCa treatment by modulating ribosome biogenesis.
Keywords:
RPA135RPA194UBTFapoptosishoneynucleolar stresspancreatic cancer (PanCa)proliferationribosome biogenesis

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