Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tics with combined thioridazine-methylphenidate therapy: case report.

C D Casat, D C Wilson

    The Journal of Clinical Psychiatry
    |January 1, 1986
    PubMed
    Summary

    Concurrent treatment with thioridazine and methylphenidate in a child led to persistent head and shoulder tics. This case highlights potential dopaminergic involvement and risks associated with this drug combination.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Physical review letters·2024
    Same author

    Modeling of a spatially resolved ion temperature diagnostic for inertial confinement fusion.

    The Review of scientific instruments·2023
    Same author

    Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

    Physical review letters·2022
    Same author

    Case Reported.

    The Southern medical record·2022
    Same author

    Comparing Effectiveness of a Generic Oral Nutritional Supplement With Specialized Formula in the Treatment of Active Pediatric Crohn's Disease.

    Inflammatory bowel diseases·2022
    Same author

    Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN.

    Alimentary pharmacology & therapeutics·2018

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Pediatrics

    Background:

    • Methylphenidate is a central nervous system stimulant commonly prescribed for Attention Deficit Hyperactivity Disorder (ADHD).
    • Thioridazine is an antipsychotic medication that can affect dopamine receptors.
    • Concurrent administration of these medications is not standard practice and carries potential risks.

    Observation:

    • A 10-year-old male patient presented with new-onset, persistent tics affecting the head and shoulders.
    • These symptoms emerged during treatment with a combination of thioridazine and methylphenidate.
    • The tics were characterized by involuntary movements of the head and shoulder region.

    Findings:

    • The development of persistent tics suggests a potential adverse drug reaction.
    • Dopaminergic pathways are implicated, as both medications can influence dopamine neurotransmission.
    • The combination therapy may exacerbate or unmask tic disorders in susceptible individuals.

    Implications:

    • Clinicians should exercise caution when considering concurrent use of thioridazine and methylphenidate, especially in pediatric patients.
    • Further research is warranted to understand the neurobiological mechanisms underlying this adverse event.
    • This case underscores the importance of vigilant monitoring for neurological side effects during combined psychotropic medication use.

    Related Experiment Videos