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Perspectives on the Dementia Public Health Exposome
Christine Noelle Flaherty1, Pam V O'Neal2, Patricia A Carter3
1School of Nursing, The University of Alabama in Huntsvlle College of Nursing, Huntsville, Alabama, USA.
Public Health Nursing (Boston, Mass.)
|October 16, 2024
Summary
Understanding the dementia exposome is key to reducing dementia risk. This framework helps identify genetic, environmental, and behavioral factors for better brain health interventions and public health strategies.
Area of Science:
- Public Health
- Epidemiology
- Gerontology
Background:
- Dementia affects 55 million globally, posing a significant public health challenge.
- Early dementia precursors can be undetected for up to 20 years.
- Minimizing dementia risk factors is crucial for at-risk populations.
Purpose of the Study:
- To introduce the dementia public health exposome (DPHE) framework.
- To provide a comprehensive approach to understanding dementia risk factors.
- To inform public health strategies for dementia prevention and healthy brain initiatives.
Main Methods:
- Exposomics approach considering modifiable and non-modifiable risk factors.
- Integration of genetic, environmental, social, and behavioral exposures.
- Framework development for analyzing complex risk factor interactions.
Main Results:
- The DPHE framework integrates genetics, health behavior, and environment.
- It addresses both modifiable and non-modifiable dementia risk factors.
- The framework facilitates understanding of lifetime exposures and their impact.
Conclusions:
- The DPHE offers a novel framework for dementia research and public health.
- Application of the DPHE can promote targeted interventions and risk mitigation.
- It supports advancements in healthy brain initiatives and dementia prevention strategies.
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