Related Experiment Video
Updated: Jun 10, 2025
Induction of Complete Transection-Type Spinal Cord Injury in Mice
Published on: May 6, 2020
Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model
Carlos César Bravo-Reyna1, Vladimir Miranda-Galván1, Gervith Reyes-Soto2
1Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico.
Background:
Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology.
Methods:
An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model.
Results:
Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression.
Conclusions:
Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated.
