Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

152
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
152
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

3.9K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
3.9K
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

701
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
701

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restarting Oral Anticoagulation in Patients With Atrial Fibrillation After Admission for a Gastrointestinal Bleeding Event: Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin.

Pharmacotherapy·2025
Same author

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2025
Same author

Gluten-Free Options for the Top 100 Pediatric Medications.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2025
Same author

Medication Utilization Among Children With Sickle Cell Disease in the United States.

Pediatric blood & cancer·2025
Same author

The Pharmacist's Role in the Care of Pediatric Emergency Department Patients.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2025
Same author

Incorporating Pediatrics in Clinical Education: A Call to Action in Inpatient Pharmacy Practice.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2025

Related Experiment Video

Updated: Jun 10, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.0K

Medication Dosing for Children With Overweight and Obesity.

Kelly L Matson1,2, Evan R Horton3,4, Amanda C Capino5,6

  • 1University of Rhode Island College of Pharmacy (KLM), Kingston, RI.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|October 16, 2024
PubMed
Summary

Pediatric obesity presents dosing challenges for medications. Guidelines recommend weight-based dosing for children under 40 kg and pharmacokinetic analysis for overweight or obese children to ensure safe and effective medication use.

Keywords:
drug dosage calculationsdrug therapyobeseoverweightpediatricspharmacokineticstherapeutic drug monitoring

More Related Videos

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

4.4K

Related Experiment Videos

Last Updated: Jun 10, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.0K
Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

4.4K

Area of Science:

  • Pediatric pharmacology
  • Clinical pharmacy
  • Obesity medicine

Background:

  • Over 14.7 million US children and adolescents (2-19 years) are obese.
  • Obesity complicates weight-based medication dosing (mg/kg) and pharmacokinetic predictions in pediatric patients.
  • Altered volume of distribution and hepatic clearance in obese children impact drug disposition.

Purpose of the Study:

  • To address challenges in pediatric medication dosing due to obesity.
  • To provide recommendations for optimizing medication administration in overweight and obese children.
  • To highlight the need for further research in pediatric pharmacokinetics and obesity.

Main Methods:

  • This is a position statement from the Pediatric Pharmacy Association.
  • Review of existing literature on pharmacokinetics in pediatric obesity.
  • Development of dosing recommendations based on patient weight and clinical considerations.

Main Results:

  • Weight-based dosing is recommended for patients <18 years weighing <40 kg.
  • For patients ≥40 kg, weight-based dosing is advised unless it exceeds the standard adult dose.
  • Pharmacokinetic analysis is recommended for medication adjustment in overweight and obese children.

Conclusions:

  • Standard weight-based dosing requires careful consideration in pediatric obesity.
  • Individualized dosing strategies, including pharmacokinetic analysis, are crucial for this population.
  • Continued research is essential to refine medication dosing for children with overweight and obesity.