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Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism.
The Journal of Clinical Endocrinology and Metabolism
|February 1, 1986
Summary
This study details a patient with severe neonatal hyperparathyroidism exhibiting parathyroid cells resistant to calcium regulation. This resistance led to life-threatening hypercalcemia, highlighting an unusual PTH secretory control abnormality.
Area of Science:
- Endocrinology
- Genetics
- Cell Biology
Background:
- Neonatal severe primary hyperparathyroidism (NSHPT) presents with life-threatening hypercalcemia.
- Parathyroid hormone (PTH) secretion is normally regulated by calcium levels.
- Genetic factors can lead to familial forms of NSHPT.