Regulatory, diagnostic, and therapeutic roles of microRNAs in chronic liver diseases
Razieh Kazemzadeh1, Maryam Kheirollahi2, Seyed Ali Mard3
1Department of Physiology, Ahvaz University of Medical Sciences, Ahvaz, Iran.
Abstract:
Fibrogenesis is initially performed during tissue damage to protect the remaining tissues from the progressive death of epithelial cells, infiltration of immune and inflammatory cells, and local degrading enzymes. Inflammation can lead to excessive extracellular matrix deposition by fibroblasts and the induction of fibrosis in many organs, such as the liver. MiRNAs are small noncoding RNAs that mediate mRNA repression or destabilization, leading to translational repression. Owing to the wide range of roles of miRNAs in the development of fibrosis, especially liver fibrosis, many studies have focused on their diagnostic, regulatory, and therapeutic roles. In this study, we used medical science and general databases, including PubMed, Elsevier, Scopus, Nature, and Google Scholar, to find valid studies on the different roles of miRNAs in liver fibrosis. Because a large number of miRNAs with regulatory, diagnostic, and therapeutic roles in diseases associated with liver fibrosis have been identified and reported in this study, special attention to these elements is needed in the future of healthcare systems.
Insights
MicroRNAs (miRNAs) play crucial roles in liver fibrosis development. This study highlights their diagnostic, regulatory, and therapeutic potential in managing this condition.
Area of Science:
- Biomedical Science
- Molecular Biology
- Gastroenterology
Background:
- Fibrogenesis is a protective tissue repair mechanism.
- Chronic inflammation can lead to excessive extracellular matrix deposition and fibrosis, particularly in the liver.
- MicroRNAs (miRNAs) are key regulators of gene expression, influencing cellular processes.
Purpose of the Study:
- To review the diverse roles of miRNAs in liver fibrosis.
- To identify miRNAs with diagnostic, regulatory, and therapeutic potential in liver fibrosis.
- To emphasize the importance of miRNAs in future liver fibrosis management.
Main Methods:
- Comprehensive literature search of medical and general databases (PubMed, Elsevier, Scopus, Nature, Google Scholar).
- Identification and analysis of studies focusing on miRNA roles in liver fibrosis.
- Synthesis of findings regarding miRNA regulation, diagnosis, and therapy.
Main Results:
- Numerous miRNAs have been identified with significant roles in liver fibrosis.
- These miRNAs exhibit potential as biomarkers for diagnosis.
- miRNAs demonstrate regulatory functions and therapeutic possibilities in liver fibrosis.
Conclusions:
- miRNAs are critical players in the intricate processes of liver fibrogenesis.
- Targeting miRNAs offers promising avenues for novel diagnostic and therapeutic strategies for liver fibrosis.
- Future healthcare systems should integrate miRNA-based approaches for improved liver fibrosis management.
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