Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Should the intent of testing influence its interpretation?

A Rozanski, G A Diamond, J S Forrester

    Journal of the American College of Cardiology
    |January 1, 1986
    PubMed
    Summary

    Exercise ejection fraction provides the most valuable diagnostic information for coronary artery disease and functional evaluation in post-infarction patients, outperforming rest ejection fraction. This study analyzed test interpretation accuracy using information content.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First Evidence of Solar Neutrino Interactions on ^{13}C.

    Physical review letters·2026
    Same author

    Measurement of Reactor Antineutrino Oscillation at SNO.

    Physical review letters·2025
    Same author

    Comparison of antimicrobial resistant Enterobacterales isolates from the dairy production environment in low and high zinc containing regions.

    The Science of the total environment·2024
    Same author

    Characterization of antimicrobial resistant Enterobacterales isolated from spinach and soil following zinc amendment.

    Environmental pollution (Barking, Essex : 1987)·2024
    Same author

    The implementation of a hepatitis C testing service in community pharmacies: I-COPTIC consensus statement.

    Public health·2024
    Same author

    Patient preferences for key drivers and facilitators of adoption of mHealth technology to manage depression: A discrete choice experiment.

    Journal of affective disorders·2023

    Area of Science:

    • Cardiology
    • Medical Diagnostics
    • Information Theory in Medicine

    Background:

    • Traditional interpretation of medical tests often relies on a single criterion, potentially overlooking the intent of testing.
    • The discriminate accuracy of such conventions requires critical analysis using quantitative methods.

    Purpose of the Study:

    • To critically analyze the discriminate accuracy of ejection fraction variables in relation to specific diagnostic and prognostic goals.
    • To compare the information content of ejection fraction at rest, exercise ejection fraction, and the change in ejection fraction.

    Main Methods:

    • Information content (I), likelihood ratio, and area under the receiver-operating characteristic curve were used for analysis.
    • Three ejection fraction variables were assessed: rest, exercise, and change from rest to exercise.

    Related Experiment Videos

  • Analysis was performed relative to three goals: diagnosis of coronary artery disease, prediction of multivessel disease in patients without prior myocardial infarction, and prediction of multivessel disease in patients with prior myocardial infarction.

    • Main Results:

    • Exercise ejection fraction (IEX) consistently showed higher information content than ejection fraction at rest (IR) or the change (IEX-R), irrespective of the testing goal.
    • The information content of IR and IEX-R varied with the testing goal; IR was lowest for diagnosing coronary artery disease, while IEX-R was highest for this goal.
    • Empiric findings align with information theory predictions: IEX = IR + IEX-R.

    Conclusions:

    • Ejection fraction at rest has limited value for diagnosing coronary artery disease but is useful for assessing disease extent post-myocardial infarction.
    • Exercise ejection fraction and the change in ejection fraction offer similar diagnostic utility for coronary artery disease.
    • Exercise ejection fraction is most valuable for functional evaluation in patients post-myocardial infarction.