Constructing the Enamel-Like Dentin Adhesion Interface to Achieve Durable Resin-Dentin Adhesion.

Area of Science:

• Biomaterials Science
• Dental Materials
• Nanotechnology

Background:

• Durable enamel adhesion is achievable, but long-lasting dentin adhesion is challenging due to collagen matrix degradation after acid-etching.
• Developing an enamel-like adhesion interface offers a promising solution for enduring dentin bonding.

Purpose of the Study:

• To construct an enamel-like adhesion interface for durable dentin adhesion using a rapid remineralization strategy.
• To address collagen degradation and enhance the longevity of dental restorations.

Main Methods:

• Utilized a 10-methacryloyloxydecyl dihydrogen phosphate (MDP) and epigallocatechin-3-gallate (EGCG) nanocomplex (MDP@EGCG primer) for partial dentin demineralization.
• Applied a polyaspartate (Pasp) stabilized amorphous calcium and phosphorus nanoclusters (rapid Pasp-CaP) medium for rapid collagen remineralization.
• Evaluated the generated interface's properties and adhesion durability both in vitro and in vivo.

Main Results:

• The strategy successfully created an inorganic, rough, and porous adhesive interface mimicking etched enamel.
• The MDP@EGCG primer demonstrated strong interaction with exposed collagen, enhancing remineralization.
• Achieved durable dentin adhesion in vitro and in vivo, overcoming collagen exposure issues.

Conclusions:

• The developed rapid remineralization strategy effectively generates an enamel-like interface for durable dentin adhesion.
• This user-friendly approach shows potential for prolonging the lifespan of adhesive restorations.
• The strategy holds promise for treating caries, dentin sensitivity, and in collagen-based tissue engineering.