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Pseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.

Ozlem Erdem¹, Barbara Corti², Francesco Paolo Salamone^3,4

¹Department of Pathology, Faculty of Medicine, Gazi University, Besevler/Ankara, Turkiye.

The American Journal of Dermatopathology

|October 16, 2024

Summary

Pseudolipoblastic perineurioma, a rare extraneural tumor, features vacuolated cells resembling lipoblasts. Simple excision is the recommended treatment for this benign condition.

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Area of Science:

Pathology
Oncology

Background:

Pseudolipoblastic perineurioma is an exceptionally rare variant of extraneural perineurioma.
Limited documented cases exist in medical literature, highlighting its rarity.

Observation:

The primary histopathologic feature is the presence of vacuolated cells that mimic lipoblasts.
These cells coexist with small, spindle-shaped, or epithelioid perineurial cells.

Findings:

This study details a case predominantly exhibiting vacuolated "pseudolipoblastic" cells.
Immunohistochemical markers such as EMA, Glut-1, claudin-1, collagen type IV, and laminin, alongside S-100 negativity, are crucial for diagnosis.
These markers confirm the perineurial cell origin.

Implications:

Accurate diagnosis is vital to distinguish pseudolipoblastic perineurioma from other vacuolated tumors.
Simple excision is curative for this benign tumor, with no reported recurrence or metastasis.
Recognition of this rare entity aids in appropriate patient management and treatment planning.