Primordial Odontogenic Tumor: A Decade Post-Description Systematic Review

Area of Science:

• Oral pathology
• Odontogenic tumors
• Pediatric dentistry

Background:

• Primordial odontogenic tumor (POT) is a rare benign neoplasm originating from odontogenic epithelium and ectomesenchyme.
• POT commonly affects children and young adults, often presenting as asymptomatic swelling in the posterior mandible.

Purpose of the Study:

• To conduct a systematic review and comprehensively analyze the clinicopathologic features of Primordial odontogenic tumors (POT) over the past decade.
• To provide current descriptive data to aid clinicians and pathologists in accurate diagnosis and management of POT.

Main Methods:

• A systematic review of Primordial odontogenic tumor (POT) case series and reports was performed adhering to PRISMA guidelines.
• Data extracted included demographics, clinical presentation, radiographic and histological features, treatment, and recurrence.
• Immunohistochemical studies were quantitatively described.

Main Results:

• The review included 36 Primordial odontogenic tumor (POT) cases from 26 studies, with a median age of 12 years and a male-to-female ratio of 1.18:1.
• The posterior mandible was the most frequent location; lesions typically appeared as unilocular radiolucencies.
• Ectomesenchymal stroma with columnar cells and nuclear reverse polarity were key histological findings; enucleation and curettage was the most common treatment (50.0%).

Conclusions:

• This systematic review provides comprehensive data on Primordial odontogenic tumor (POT) clinicopathologic features.
• Enhanced understanding aids clinicians and pathologists in accurate identification, preventing misdiagnosis and inappropriate management of this rare odontogenic tumor.