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Published on: May 13, 2020
Talauromides A-G, Nitrogen-Containing Heptacyclic Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus
Shikun Zong1,2, Yixuan Zhang1,2, Jun Xiao1,2
1School of Pharmacy, Bengbu Medical University, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
Abstract:
Seven new nitrogen-containing heptacyclic oligophenalenone dimers, talauromides A-G (1-7), together with known compounds bacillisporins A and B (8 and 9), talaromycesones C and B (10 and 11), duclauxin (12) and lamellicolic anhydride (13), were isolated from the soil derived-fungus Talaromyces stipitatus BMC-16. Their chemical structures were determined based on spectroscopic analysis data. The absolute configurations were elucidated by chemical approaches and the comparison of CD spectra with related compounds. Compounds 3, 8 and 11 exhibited inhibitory activity on the Wnt/β-catenin signaling pathway in zebrafish embryos at a concentration of 20 μM.
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