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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Oxaliplatin-induced transient ischemic attack (TIA): A rare presentation.

Vikas K Jagtap1, Baiakmenlang Synmon2, Deiwakor Chyrmang1

  • 1Department of Radiation Oncology, NEIGRIHMS, Shillong, Meghalaya, India.

Journal of Cancer Research and Therapeutics
|October 16, 2024
PubMed
Summary

Oxaliplatin can cause rare neurological side effects. This case study details a transient ischemic attack (TIA)-like event occurring after the second dose of oxaliplatin, highlighting a delayed onset of neurotoxicity.

Area of Science:

  • Oncology
  • Neurology
  • Pharmacology

Background:

  • Oxaliplatin is a cornerstone chemotherapy agent for colorectal cancer.

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  • Neurological adverse events associated with oxaliplatin are documented but typically manifest early in treatment.
  • Reported neurological side effects include amaurosis fugax, stroke, and cranial nerve palsies.