Related Experiment Video

Updated: Jun 10, 2025

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

17.9K

Mechanisms of RET-mediated signal transduction

Francesca Carlomagno, Marialuisa Moccia, Giorgia Federico

    Endocrine-Related Cancer
    |October 16, 2024
    PubMed

    Insights

    The rearranged during transfection (RET) receptor tyrosine kinase is vital for development and disease. This review explores RET signaling pathways and their role in human health and illness.

    Area of Science:

    • Molecular Biology
    • Cell Signaling
    • Oncology

    Background:

    • The rearranged during transfection (RET) receptor tyrosine kinase is a key signaling molecule.
    • RET is activated by glial cell line-derived neurotrophic factor family ligands and growth differentiation factor-15.
    • Dysregulation of RET signaling is implicated in various human pathologies.

    Purpose of the Study:

    • To review the mechanisms of RET receptor tyrosine kinase signaling.
    • To examine how RET signaling alterations contribute to human diseases.
    • To provide an overview of RET's role in development and cancer.

    Main Methods:

    • Literature review of scientific publications on RET signaling.
    • Analysis of studies investigating RET mutations and pathway dysregulation.
    • Synthesis of information on RET's physiological and pathological functions.

    Main Results:

    • RET signaling is complex, involving multiple downstream effectors.
    • Aberrant RET activation drives oncogenesis in several tumor types.
    • RET pathway alterations are linked to developmental abnormalities.

    Conclusions:

    • Understanding RET signaling mechanisms is crucial for therapeutic development.
    • Targeting RET pathways offers potential for treating RET-driven cancers and developmental disorders.
    • Further research into RET biology will illuminate its multifaceted roles.
    Keywords:
    cancergrowth factorhereditary cancerkinasethyroid

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