Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells.

World journal of gastroenterology·2007
Same author

A population-based survey of women's traditional postpartum behaviours in Northern China.

Midwifery·2007
Same author

A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates.

PloS one·2007
Same author

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.

Molecular cancer therapeutics·2007
Same author

[Surgical treatment of 402 consecutive cases for hilar cholangiocarcinoma: Chinese single center experience].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2007
Same author

Highly convergent route to cyclopeptide alkaloids: total synthesis of ziziphine N.

Organic letters·2007
Same journal

High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial.

Cell reports. Medicine·2026
Same journal

Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation.

Cell reports. Medicine·2026
Same journal

Multi-omics profiling unveils biological and clinical insights into pulmonary sarcomatoid carcinoma.

Cell reports. Medicine·2026
Same journal

Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4<sup>+</sup>CD8<sup>+</sup> T cells.

Cell reports. Medicine·2026
Same journal

Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors.

Cell reports. Medicine·2026
Same journal

Advancing CAR-NK cell therapy in solid tumors: Current landscape and future directions.

Cell reports. Medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.0K

Closed-loop neural interfaces for pain: Where do we stand?

Jing Wang1, Zhe Sage Chen2

  • 1Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University Grossman School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, USA; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA; Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, NY, USA; Interdisciplinary Pain Research Program, NYU Langone Health, New York, NY, USA.

Cell Reports. Medicine
|October 16, 2024
PubMed
Summary
This summary is machine-generated.

Closed-loop neural interfaces offer a non-addictive treatment for chronic pain by precisely stimulating nerves. Current research explores their use in animal models and human trials for pain management.

More Related Videos

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

1.2K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.5K

Related Experiment Videos

Last Updated: Jun 3, 2026

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.0K
Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

1.2K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.5K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pain Management

Background:

  • Chronic pain affects millions globally, with limited non-addictive treatment options.
  • Neuromodulation and neural interfaces represent a promising avenue for pain relief.
  • Current treatments often carry risks of addiction and side effects.

Purpose of the Study:

  • To review the current state of closed-loop neural interfaces for pain treatment.
  • To discuss the challenges and future trends in this rapidly evolving field.
  • To highlight applications in both animal models and human pilot studies.

Main Methods:

  • Review of state-of-the-art neural interface technologies.
  • Analysis of closed-loop systems integrating neural sensing and stimulation.
  • Examination of data from preclinical animal studies and early-phase human trials.

Main Results:

  • Closed-loop systems demonstrate potential for precise, adaptive pain modulation.
  • Successful application in animal models suggests therapeutic viability.
  • Early human pilot trials show promise for chronic pain management.

Conclusions:

  • Closed-loop neural interfaces are a developing, non-addictive therapeutic strategy for chronic pain.
  • Further research and clinical translation are needed to optimize efficacy and safety.
  • These technologies hold significant potential to revolutionize pain treatment paradigms.