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Injectable hydrogel microsphere-bomb for MRSA-infected chronic osteomyelitis
Summary
A novel ultrasound-triggered hydrogel microsphere-bomb effectively eradicates bacterial biofilms and promotes bone repair in chronic osteomyelitis. This intelligent drug delivery system offers a promising solution for orthopedic infections.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Tissue Engineering
Background:
- Chronic osteomyelitis is challenging due to bacterial biofilms and bone defects.
- Effective drug delivery to infected bone sites is hindered by dense biofilms.
Purpose of the Study:
- To develop an acoustically responsive multifunctional hydrogel microsphere-bomb (EMgel) for targeted drug delivery.
- To investigate the efficacy of EMgel in eradicating biofilms and promoting bone regeneration in osteomyelitis.
Main Methods:
- Microfluidic technology was used to prepare EMgel encapsulating EGCG and MoS2.
- EMgel was designed to release contents upon ultrasound stimulation to disrupt biofilms.
- In vitro and in vivo studies were conducted using a Methicillin-resistant Staphylococcus aureus (MRSA) infected chronic osteomyelitis model.
Main Results:
- EMgel demonstrated controlled drug release, 99% antibacterial efficacy, biofilm resistance, antioxidation, and cytocompatibility.
- Ultrasound-triggered EMgel effectively eradicated biofilms and promoted bone regeneration.
- Reduced inflammation and increased osteocalcin (OCN) expression were observed in the EMgel + ultrasound group.
Conclusions:
- EMgel is an innovative intelligent drug delivery system for osteomyelitis treatment.
- The synergistic effects of EGCG and MoS2, combined with ultrasound, enhance biofilm eradication and bone repair.
- This approach shows significant potential for treating chronic orthopedic infections and advancing tissue engineering.
