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Initial Experience Using a Shear-Thinning Conformable Hydrogel Embolic.

Elena Drews1, Ashley Yearwood1, Siddharth A Padia1

  • 1Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at University of California, Los Angeles, California.

Journal of Vascular and Interventional Radiology : JVIR
|October 16, 2024
PubMed
Summary
This summary is machine-generated.

A novel shear-thinning embolic agent demonstrated high technical and clinical success in embolizing tumors and treating bleeding. Operator training is crucial due to its unique properties compared to conventional embolics.

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Area of Science:

  • Interventional Radiology
  • Biomaterials Science
  • Vascular Surgery

Background:

  • A new conformable embolic agent, Obsidio, is a non-Newtonian hydrogel designed for embolization procedures.
  • This agent exhibits shear-thinning properties, reducing viscosity under applied force.

Purpose of the Study:

  • To evaluate the safety and effectiveness of this novel shear-thinning embolic agent.
  • To assess technical success, clinical success, and adverse events in a single-academic-center retrospective study.

Main Methods:

  • Retrospective review of 27 patients undergoing 28 procedures.
  • 39 vessels were treated with the shear-thinning embolic agent.
  • Assessment of technical and clinical outcomes, and adverse events.

Main Results:

  • High technical success rate of 95% (37/39 vessels).
  • High clinical success rate of 93% (26/28 procedures).
  • One severe adverse event (3.6%) involving gastric ischemia and subtotal gastrectomy; two mild adverse events (7.1%).

Conclusions:

  • The shear-thinning embolic agent shows initial effectiveness for embolization and bleeding treatment.
  • Its unique behavior necessitates specific operator training for safe and effective use.
  • Further investigation into its distinct properties compared to conventional liquid embolics is warranted.