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Cryptosporidiosis in individuals with inflammatory bowel disease: a scoping review protocol
Belinda Liu1, Alexander Schnider1, Megan DeArmond2,3
1College of Osteopathic Medicine, Touro University Nevada, Henderson, Nevada, USA.
Introduction:
Cryptosporidiosis is a leading cause of moderate-to-severe diarrhoea globally, and, while it is often self-limited, in immunocompromised individuals, the infection can be associated with significant morbidity and mortality. Diagnosis might be missed or delayed in patients with inflammatory bowel disease (IBD) due to similar presentation, and these patients may also be on immunosuppressive therapies, increasing their risk of infection. Additionally, gastrointestinal infection and dysbiosis may be a risk factor for IBD. Diagnosis, presentation and treatment of cryptosporidiosis in individuals with IBD, as well as any epidemiologic correlations between the two diseases, will be investigated.
Methods And Analysis:
MEDLINE, Embase, Cochrane Library, CINAHL, Dissertations and Theses Global and grey literature will be searched. Joanna Briggs Institute (JBI) methodology for scoping reviews was used for the protocol and will be for the review. Two reviewers will independently screen studies and extract data. The evidence and presentation of the results will be analysed with input from the review team. Studies of cryptosporidiosis in patients with IBD will be included. Paediatric, adolescent and adult studies in all patient environments will be included. Cases in which Crohn's disease does not affect the intestine and cases in which cryptosporidial infection is not in the intestine will be excluded.
Ethics And Dissemination:
Published clinical literature will be systematically reviewed, and this work does not directly involve patients. Consequently, ethical review by an institutional review board is not required. Data will be presented at academic conferences, and a culminating report will be published in a peer-reviewed journal. OPEN SCIENCE FRAMEWORK REGISTRATION: https://osf.io/j47mb.
Insights
This review investigates cryptosporidiosis in inflammatory bowel disease (IBD) patients, examining diagnosis, presentation, treatment, and potential links between these conditions. Understanding this relationship is crucial for managing immunocompromised individuals with IBD.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Epidemiology
Background:
- Cryptosporidiosis is a major cause of diarrhea globally, posing risks to immunocompromised individuals.
- Inflammatory Bowel Disease (IBD) patients on immunosuppressants are at increased risk.
- Similar symptoms can delay cryptosporidiosis diagnosis in IBD patients.
Purpose of the Study:
- To systematically review the diagnosis, presentation, and treatment of cryptosporidiosis in IBD patients.
- To explore potential epidemiologic correlations between cryptosporidiosis and IBD.
- To synthesize current evidence on managing this dual condition.
Main Methods:
- A comprehensive scoping review of multiple databases (MEDLINE, Embase, Cochrane, CINAHL) and grey literature.
- Adherence to Joanna Briggs Institute (JBI) methodology for scoping reviews.
- Independent screening and data extraction by two reviewers.
Main Results:
- Evidence on diagnosis, clinical presentation, and treatment of cryptosporidiosis in IBD patients will be synthesized.
- Epidemiologic links between cryptosporidiosis and IBD will be analyzed.
- Data from pediatric, adolescent, and adult studies will be included.
Conclusions:
- This review will provide a comprehensive overview of cryptosporidiosis in IBD.
- Findings will inform clinical practice and highlight areas for future research.
- Understanding the interplay between these conditions is vital for patient outcomes.
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