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YTHDC1-mediated microRNA maturation is essential for hematopoietic stem cells maintenance

Hongna Zuo1,2, Jin Liu1,2, Bin Shen3

  • 1Department of Hematology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Cell Death Discovery
|October 16, 2024
PubMed
Summary

The nuclear protein YTHDC1 is crucial for maintaining hematopoietic stem cell (HSC) function and self-renewal by regulating microRNA maturation. Its absence leads to HSC loss, highlighting the YTHDC1-HP1BP3-microRNA axis

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